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Related Experiment Video

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Generation of Alginate Microspheres for Biomedical Applications
10:33

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Published on: August 12, 2012

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Preparation methods and applications behind alginate-based particles.

Marlene Lopes1,2, Barbara Abrahim3, Francisco Veiga1,2

  • 1a University of Coimbra , Coimbra , Portugal.

Expert Opinion on Drug Delivery
|August 6, 2016
PubMed
Summary
This summary is machine-generated.

Alginate particles are versatile drug delivery systems due to their biocompatibility and biodegradability. This review covers innovative preparation methods, applications, and safety of alginate microparticles and nanoparticles.

Keywords:
Biological encapsulantdrug deliveryhydrogelnanoparticle safetypolysaccharide

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Alginate-based particles are extensively researched drug delivery platforms.
  • Their properties include biocompatibility, biodegradability, low cost, and natural origin.
  • Alginate's sol-gel transition property facilitates particle production for diverse applications.

Purpose of the Study:

  • To review alginate-based delivery systems.
  • To cover innovative preparation methods from the last decade.
  • To discuss advantages, disadvantages, applications, and safety concerns.

Main Methods:

  • Overview of various techniques for preparing alginate microparticles and nanoparticles.
  • Analysis of optimized procedures for efficiency and cost-effectiveness.
  • Exploration of nanotechnology advancements in submicron scale particle preparation.

Main Results:

  • Alginate particles are suitable for drug delivery, especially for biological encapsulants.
  • Nanotechnology has refined microencapsulation and spurred new submicron approaches.
  • Increased focus on nanoparticle safety, performance, nontoxicity, and biocompatibility.

Conclusions:

  • Alginate-based particles are a safe and effective choice for drug delivery systems.
  • Optimization of preparation methods enhances product performance and safety.
  • Further research explores nontoxicity, biocompatibility, and biodegradability for targeted applications.