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Acid-triggered release of doxorubicin from a hydrazone-linked Gd(3+)-texaphyrin conjugate
Min Hee Lee1, Eun-Joong Kim2, Hyunseung Lee2
1Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea. minheelee@sookmyung.ac.kr.
Abstract:
The hydrazone-based Gd(3+)-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off-On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.

