Atheromatous embolism: varied clinical presentation and prognosis

Microemboli composed of atheromatous debris can produce sudden failure of one or many organ systems. The soft tissues of the lower extremity are almost always involved, and may sustain the only significant injury. Atheromatous embolization occurs more commonly than is recognized, and its incidence may be increasing. We report ten cases that demonstrate the variability in presentation and prognosis. These data and a review of the existing literature suggest an extremely grave prognosis in patients with generalized organ system involvement, as opposed to those patients with involvement of the lower extremity only. Treatment consists of general supportive care. Anticoagulation or lytic therapy appears to be of no benefit, and may actually contribute to embolization. We discuss new pharmacologic agents as possible treatment for the intense local ischemia, and recommend selective use of lumbar sympathectomy in cases of impending loss of lower extremity tissue.