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Medication-overuse headache: a perspective review

Maria Lurenda Westergaard1, Signe Bruun Munksgaard2, Lars Bendtsen2

  • 1Danish Headache Center, Rigshospitalet - Glostrup, University of Copenhagen, Nordre Ringvej 67, Område Nord Bygning 14, 2600 Glostrup, Denmark.

Therapeutic Advances in Drug Safety
|August 6, 2016
PubMed

Insights

Medication-overuse headache (MOH) is a common, debilitating condition where frequent pain medication use worsens headaches. Reviewing recent literature highlights the need for research into MOH epidemiology, pathophysiology, and effective treatment protocols for global health improvement.

Area of Science:

  • Neurology
  • Public Health

Background:

  • Medication-overuse headache (MOH) is a prevalent neurological disorder.
  • It significantly contributes to the global burden of disease, affecting 1-7% of the population.
  • MOH disproportionately affects women and individuals with lower socioeconomic status.

Purpose of the Study:

  • To review the latest scientific literature on medication-overuse headache.
  • To identify and discuss future research directions in the field of MOH.

Main Methods:

  • Comprehensive literature review of recent studies on MOH.
  • Analysis of epidemiological data, pathophysiology, and neuroimaging findings.
  • Evaluation of current and proposed treatment strategies.

Main Results:

  • MOH management involves medication withdrawal, prophylactic treatments, and lifestyle interventions.
  • Patient support, education, and follow-up are crucial during detoxification.
  • Significant research gaps exist in MOH epidemiology, pathophysiology, and neuroimaging.

Conclusions:

  • Further research, including randomized controlled trials and long-term follow-up studies, is essential for optimizing MOH treatment.
  • Addressing MOH is critical for improving global health outcomes.
  • Integrated approaches combining medical and non-medical interventions show promise.
Keywords:
chronic headacheepidemiologymedication-overuse headachetreatment

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