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Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases

Ren-Peng Zhou1, Xiao-Shan Wu1, Zhi-Sen Wang1

  • 11Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, Hefei 230032, China; 2The Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei 230032, China.

Aging and Disease
|August 6, 2016
PubMed

Insights

Acid-sensing ion channels (ASICs) are increasingly implicated in degenerative diseases like arthritis and Parkinson's. Targeting ASICs offers a promising therapeutic strategy for these conditions.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pathology

Background:

  • Degenerative diseases involve progressive cell and tissue deterioration with limited treatments.
  • Acid-sensing ion channels (ASICs) are crucial in physiological and pathological processes.
  • ASICs regulate key cellular functions like apoptosis, differentiation, and autophagy.

Purpose of the Study:

  • To review the critical roles of ASICs in various degenerative diseases.
  • To explore the potential of ASICs as therapeutic targets.

Main Methods:

  • Comprehensive literature review of studies on ASICs and degenerative diseases.
  • Analysis of evidence linking ASIC activation to disease pathogenesis.
  • Evaluation of ASICs as potential therapeutic targets.

Main Results:

  • ASICs are significantly increased and activated in multiple sclerosis, Parkinson's disease, Huntington's disease, intervertebral disc degeneration, and arthritis.
  • Aberrant ASIC activation contributes to the progression of these disorders.

Conclusions:

  • ASICs play a significant role in the pathogenesis of numerous degenerative diseases.
  • Targeting ASICs presents a promising therapeutic avenue for managing degenerative conditions.
Keywords:
acid-sensing ion channel (asic)calcium (ca2+)degenerative diseasestherapeutic target

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