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Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

Three-dimensional vertex model for simulating multicellular morphogenesis.

Satoru Okuda¹, Yasuhiro Inoue², Taiji Adachi²

¹Center for Developmental Biology, RIKEN, Kobe, Hyogo 650-0047, Japan.

Biophysics and Physicobiology

|August 6, 2016

Summary

This summary is machine-generated.

Three-dimensional (3D) vertex models simulate organ development by integrating cell mechanics and behaviors. These computational tools quantitatively model complex multicellular morphogenesis, aiding developmental biology research.

Keywords:

3D vertex model biomechanics computational simulation developmental biology reversible network reconnection

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Area of Science:

Developmental Biology
Computational Biology
Biophysics

Background:

Organ development (morphogenesis) involves complex, spatiotemporally coordinated cellular activities.
Understanding the mechanisms of three-dimensional (3D) multicellular construction is crucial.
Existing models often simplify the intricate dynamics of cell sheets and aggregates.

Purpose of the Study:

To review the general use of 3D vertex models in simulating multicellular morphogenesis.
To demonstrate the application of 3D vertex models to simplified developmental phenomena.
To highlight the capability of these models in quantitatively simulating complex 3D structures.

Main Methods:

Utilizing 3D vertex models for computational simulations of multicellular systems.
Integrating single-cell mechanics to control cellular activities like contraction, growth, division, and death.
Modeling dynamics of 3D cell sheets (monolayer/multilayer epithelia) and cell aggregates.

Main Results:

3D vertex models allow quantitative simulation of complex 3D multicellular structures.
These models provide a framework for analyzing dynamic changes in cell layers and tissue architecture.
Applications demonstrate the model's utility in studying simplified developmental processes.

Conclusions:

3D vertex models are powerful tools for investigating the mechanisms of morphogenesis.
They enable precise control over cellular behaviors to simulate tissue and organ development.
This approach facilitates a deeper understanding of how cellular activities construct 3D biological forms.