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An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment
Shijin Xia1, Xinyan Zhang2, Songbai Zheng1
1Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
Inflamm-aging, a hallmark of aging, drives numerous age-related diseases. This review explores inflamm-aging
Area of Science:
- Gerontology and immunology, focusing on the aging process and immune system changes.
Background:
- Inflamm-aging, characterized by chronic low-grade inflammation, is increasingly linked to age-related diseases.
- Diseases associated with inflamm-aging include Alzheimer's, atherosclerosis, heart disease, type II diabetes, and cancer.
Purpose of the Study:
- To review the concept, pathological features, and mechanisms of inflamm-aging.
- To explore intervention and therapeutic strategies for managing inflamm-aging in disease progression.
Main Methods:
- Comprehensive literature review of studies on inflamm-aging.
- Analysis of research on the role of inflamm-aging in disease development and progression.
Main Results:
- Significant advances have been made in understanding inflamm-aging's role in disease over the last decade.
- The precise mechanisms by which inflamm-aging influences pathological changes remain incompletely understood.
Conclusions:
- Inflamm-aging is a critical factor in aging and associated pathologies.
- Further research into the mechanisms and therapeutic interventions for inflamm-aging is warranted.
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