Biological importance of structurally diversified chromenes

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Natural Products Chemistry

Background:

• Chromene scaffolds are prevalent in natural products with diverse biological activities.
• Low toxicity and broad pharmacological properties of chromenes inspire therapeutic agent development.
• This review focuses on 2H- and 4H-chromenes from 1993 onwards.

Purpose of the Study:

• To review the biological activity of natural and synthetic 2H- and 4H-chromenes.
• To identify chromene-based natural products and their sources (plants, fruits).
• To explore synthetic chromenes as leads for drug discovery.

Main Methods:

• Literature review of scientific publications from 1993 to present.
• Categorization of chromenes into natural and synthetic origins.
• Identification of biological activities and targets.

Main Results:

• Compilation of bioactive natural chromenes from various plant and fruit sources.
• Overview of synthetic chromene derivatives with therapeutic potential.
• Identification of key biological targets including anticancer, antimicrobial, anti-inflammatory, antithrombotic, and antipsychotic activities.

Conclusions:

• Chromene derivatives, both natural and synthetic, represent a promising scaffold for drug discovery.
• Further research into chromene's biological activities can lead to novel therapeutic agents.
• The diverse pharmacological profile supports chromenes as valuable leads for various medical conditions.