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Updated: Mar 16, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel tri-substituted
Guda Mallikarjuna Reddy1, Jarem Raul Garcia1, Vemulapati Hanuman Reddy2
1Department of Chemistry, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil.
Abstract:
Trisubstituted thiazoles were synthesized and studied for their antimicrobial activity and supported by theoretical calculations. In addition, MIC, MBC and MFC were also tested. Moreover, the present study was analyzed to scrutinize comprehensive structure-activity relationships. In fact, LUMO orbital energy and orbital orientation was reliable to explain their antibacterial and antifungal assay. Amongst the tested compounds, tri-methyl-substituted thiazole compound showed higher antimicrobial activity and low MIC value due to highest LUMO energy.
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