Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

7.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.9K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

711
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
711

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-exposure prophylaxis and telemedicine during coronavirus (COVID-19): a qualitative study of the experiences of health care professionals in Mexico.

Sexual health·2024
Same author

Macrovascular and microvascular type 2 diabetes complications are interrelated in a mouse model.

Journal of diabetes and its complications·2023
Same author

CD4<sup>+</sup> T-cell activation of bone marrow causes bone fragility and insulin resistance in type 2 diabetes.

Bone·2021
Same author

Monte Carlo track-structure for the radionuclide Copper-64: characterization of S-values, nanodosimetry and quantification of direct damage to DNA.

Physics in medicine and biology·2020
Same author

Positron range effects of <sup>66</sup>Ga in small-animal PET imaging.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2019
Same author

Interprofessional training for the delivery of community health services in Mexico: the experience of Partners in Health.

Journal of interprofessional care·2019

Related Experiment Video

Updated: Mar 16, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

9.0K

Positron range in tissue-equivalent materials: experimental microPET studies.

H Alva-Sánchez1, C Quintana-Bautista, A Martínez-Dávalos

  • 1Instituto de Física, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Physics in Medicine and Biology
|August 6, 2016
PubMed
Summary

Positron range significantly impacts Positron Emission Tomography (PET) scan resolution and quantification. Careful consideration is needed for accurate standard-uptake value calculations, especially with high-energy positron emitters.

More Related Videos

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
09:41

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Published on: January 20, 2023

2.4K
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.6K

Related Experiment Videos

Last Updated: Mar 16, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

9.0K
Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
09:41

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Published on: January 20, 2023

2.4K
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.6K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Physics

Background:

  • Positron Emission Tomography (PET) is a crucial imaging modality.
  • Understanding factors affecting PET image quality is vital for accurate diagnosis.
  • Positron range is a known but often underestimated factor in PET imaging.

Purpose of the Study:

  • To experimentally investigate the influence of positron range on PET scan spatial resolution and activity quantification.
  • To measure the line spread function (LSF) in various tissue-equivalent materials.
  • To assess the impact on quantitative accuracy of standard-uptake values.

Main Methods:

  • Used line sources of (18)F, (13)N, and (68)Ga in tissue-equivalent phantoms (lung, adipose, bone, solid water).
  • Performed PET scans using a small-animal PET scanner and filtered-backprojection reconstruction.
  • Analyzed radial profiles to determine spatial resolution (FWHM, FWTenthM, etc.) and fitted LSFs with a double-Gaussian model.

Main Results:

  • Positron range demonstrably affects spatial resolution across different materials.
  • Activity concentration quantification in PET scans is significantly influenced by positron range.
  • Discrepancies were observed between measured and known activity concentrations.

Conclusions:

  • Positron range is a critical factor impacting PET spatial resolution and quantitative accuracy.
  • Standard-uptake value calculations require careful attention, particularly for high-energy positron emitters and heterogeneous tissue uptake.
  • The findings support the incorporation of LSF models into iterative reconstruction for improved PET accuracy.