Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Morphologies01:29

Microbial Morphologies

4.7K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
4.7K
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

3.9K
The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections...
3.9K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.2K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.2K
Cell Migration01:09

Cell Migration

19.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.0K
Morphogenesis02:19

Morphogenesis

30.7K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-phase field model reveals internal dissipation is crucial for spontaneous hole formation in cell monolayers.

Nature communications·2026
Same author

Mesoscale modelling of starch digestion.

Molecular physics·2026
Same author

Shape, confinement and inertia effects on the dynamics of a driven spheroid in a viscous fluid.

Soft matter·2026
Same author

Flow coupling alters topological phase transition in nematic liquid crystals.

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same author

Emergent Ordering in Active Fluids Driven by Substrate Deformations: Mechanisms and Patterning Regimes.

Physical review letters·2026
Same author

Density-velocity relation is scale-dependent in epithelial monolayers.

Soft matter·2026
Same journal

Erratum: Spectroscopy and Ground-State Transfer of Ultracold Bosonic ^{39}K^{133}Cs Molecules [Phys. Rev. Lett. 135, 203401 (2025)].

Physical review letters·2026
Same journal

Erratum: Lifetime of the ^{2}F_{7/2} Level in Yb^{+} for Spontaneous Emission of Electric Octupole Radiation [Phys. Rev. Lett. 127, 213001 (2021)].

Physical review letters·2026
Same journal

Laser-Plasma Based Seeded Free Electron Laser in the High-Gain Regime.

Physical review letters·2026
Same journal

Parent Hamiltonians for Stabilizer Quantum Many-Body Scars.

Physical review letters·2026
Same journal

Properties of Heavy Cosmic Nuclei Phosphorus, Chlorine, Argon, Potassium, and Calcium: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2026
Same journal

Role of Spin-Isospin Symmetries in Nuclear β-Decays.

Physical review letters·2026
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

7.1K

Defect-Mediated Morphologies in Growing Cell Colonies.

Amin Doostmohammadi1, Sumesh P Thampi1, Julia M Yeomans1

  • 1The Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford OX1 3NP, United Kingdom.

Physical Review Letters
|August 6, 2016
PubMed
Summary
This summary is machine-generated.

Cell division dynamics and topological defects regulate colony shape. Friction with the substrate drives growth towards isotropic morphologies by controlling defect behavior and cell reorientation.

More Related Videos

High-Throughput Live Imaging of Microcolonies to Measure Heterogeneity in Growth and Gene Expression
12:52

High-Throughput Live Imaging of Microcolonies to Measure Heterogeneity in Growth and Gene Expression

Published on: April 18, 2021

5.5K
Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host
09:24

Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host

Published on: October 12, 2022

2.4K

Related Experiment Videos

Last Updated: Mar 16, 2026

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

7.1K
High-Throughput Live Imaging of Microcolonies to Measure Heterogeneity in Growth and Gene Expression
12:52

High-Throughput Live Imaging of Microcolonies to Measure Heterogeneity in Growth and Gene Expression

Published on: April 18, 2021

5.5K
Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host
09:24

Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host

Published on: October 12, 2022

2.4K

Area of Science:

  • Cell biology
  • Biophysics
  • Mathematical modeling

Background:

  • Colony morphology is crucial for cellular physiology and evolution.
  • Understanding cell growth dynamics requires integrating cell division and collective behavior.

Purpose of the Study:

  • To investigate how cell division and topological defects influence the morphology of growing cell colonies.
  • To elucidate the role of substrate friction in regulating colony shape and defect dynamics.

Main Methods:

  • Utilized active gel equations incorporating cell division.
  • Analyzed the interplay between cell orientation, topological defects, and colony interface.
  • Investigated the influence of substrate friction on defect density and velocity.

Main Results:

  • Shape changes during colony growth are regulated by topological defect dynamics.
  • Substrate friction drives anisotropic colonies towards isotropic shapes by mediating defect density and velocity.
  • Cell division-induced stresses cause cells to reorient parallel to the colony interface.

Conclusions:

  • Topological defects and cell division are key regulators of cell colony morphology.
  • Substrate interactions play a significant role in shaping collective cell behavior and colony development.