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Related Experiment Video

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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

Anne Mourrégot1, Pierre-Emmanuel Colombo1, Philippe Rouanet1

  • 1Service de chirurgie oncologique, ICM Val d'Aurelle, Parc Euromédecine, Montpellier, France.

Bulletin Du Cancer
|August 7, 2016
PubMed
Summary

Therapeutic de-escalation in breast cancer surgery is not suitable for all patients. Careful patient selection is crucial for axillary management, mastectomy, oncoplasty, and ambulatory surgery to ensure optimal outcomes.

Keywords:
Axiiiary dissectionBreast cancer surgeryChirurgie cancer du seinCurage axillaireHospitalisationMastectomieMastectomyOncopiastyOncoplastieTraditionai hospitaiizationconventionnelle

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Therapeutic de-escalation in breast cancer surgery aims to reduce treatment intensity.
  • Patient selection is critical for the success of de-escalation strategies.

Purpose of the Study:

  • To outline the limitations and contraindications for therapeutic de-escalation in breast cancer surgery.
  • To guide clinicians in appropriate patient selection for various surgical approaches.

Main Methods:

  • Review of current guidelines and clinical evidence regarding breast cancer surgical de-escalation.
  • Analysis of patient-specific factors influencing surgical decision-making.

Main Results:

  • Sentinel lymph node biopsy has contraindications, and axillary dissection may be necessary for >3 positive nodes without adjuvant therapy.
  • Mastectomy may be preferred due to genetic mutations or oncological reasons.
  • Oncoplasty is indicated for ductal carcinoma in situ and high-risk local recurrence post-neoadjuvant therapy.
  • Ambulatory surgery is not universally applicable to all breast cancer patients.

Conclusions:

  • Therapeutic de-escalation in breast cancer surgery requires individualized patient assessment.
  • Contraindications exist for sentinel node biopsy and conservative approaches.
  • Mastectomy and oncoplasty have specific indications.
  • Ambulatory surgery is not suitable for all breast cancer patients.