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Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
Jialiang Zhu1, Haifeng Li2, Li Feng3
1Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China.
Abstract:
A case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen, M. morganii, with high diversity, which might evolve during replication within the host.
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