Related Experiment Video
Updated: Mar 16, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
Published on: December 19, 2016
Measuring inter-rater reliability for nominal data - which coefficients and confidence intervals are appropriate?
Antonia Zapf1, Stefanie Castell2, Lars Morawietz3
1Department of Medical Statistics, University Medical Center Göttingen, Humboldtallee 32, 37073, Göttingen, Germany. Antonia.Zapf@med.uni-goettingen.de.
Fleiss' kappa and Krippendorff's alpha with bootstrap confidence intervals are suitable for nominal data reliability. Krippendorff's alpha is recommended for missing data or higher-order data, and the asymptotic confidence interval for Fleiss' kappa should be avoided.
Area of Science:
- Medical research methodology
- Statistical analysis in healthcare
Background:
- Measurement reliability is crucial for medical research.
- Fleiss' kappa (Fleiss' K) and Krippendorff's alpha are flexible measures for nominal data inter-rater reliability.
- Investigating statistical properties of these measures and confidence intervals is essential.
Purpose of the Study:
- To compare Fleiss' K and Krippendorff's alpha for inter-rater reliability.
- To evaluate precision of estimates and coverage probability of confidence intervals.
- To determine suitability in various data scenarios.
Main Methods:
- Large-scale simulation study.
- Investigated precision of Fleiss' K and Krippendorff's alpha estimates.
- Assessed empirical coverage probability of asymptotic and bootstrap confidence intervals.
Main Results:
- Fleiss' K and Krippendorff's alpha point estimates were similar for complete data.
- Krippendorff's alpha provided stable estimates with missing data; Fleiss' K yielded biased estimates.
- Bootstrap confidence intervals showed accurate coverage, unlike the asymptotic interval for Fleiss' K.
Conclusions:
- Fleiss' K and Krippendorff's alpha with bootstrap CIs are suitable for complete nominal data.
- Avoid asymptotic confidence intervals for Fleiss' K.
- Krippendorff's alpha is recommended for missing data or higher-order categories.
Related Concept Videos
Kendall's Coefficient of Concordance
Ratio Level of Measurement
A set of data measured using the ratio scale takes care of the ratio problem and provides complete information. Ratio scale data are like interval scale data, except they have a zero point and ratios can be calculated....
Nominal Level of Measurement
The data that cannot be measured but can be grouped into categories fall under the nominal level of measurement. Data that is measured using a nominal...
Sign Test for Nominal Data
For example, consider a...
McNemar's Test
Ordinal Level of Measurement
Data measured using an ordinal scale are similar to nominal scale data, but there is one major difference. The ordinal scale data can be ordered. An example of ordinal scale data is a list of the top five national parks...

