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Abdo-Man: a 3D-printed anthropomorphic phantom for validating quantitative SIRT.

Jonathan I Gear1, Craig Cummings2, Allison J Craig2

  • 1Joint Department of Physics, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, Surrey, UK. jgear@icr.ac.uk.

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Summary

A 3D-printed anthropomorphic phantom was developed for validating selective internal radiation therapy (SIRT) dosimetry. This cost-effective tool enables accurate quantitative imaging and dosimetry evaluation for improved patient outcomes.

Keywords:
3D printingDosimetryMicrospheresPhantomsQuantificationSIRT

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Area of Science:

  • Medical Imaging
  • Radiotherapy Physics
  • Biomedical Engineering

Background:

  • Selective internal radiation therapy (SIRT) use is increasing, necessitating advanced methods for treatment planning and verification.
  • Accurate dosimetry is crucial for effective SIRT, requiring reliable validation tools.
  • Current validation methods may not fully address the complexities of post-SIRT imaging.

Purpose of the Study:

  • To develop a novel anthropomorphic phantom for validating post-SIRT imaging and dosimetry.
  • To create a realistic anatomical model for testing quantitative imaging techniques.
  • To establish a benchmark for assessing dosimetry accuracy in SIRT.

Main Methods:

  • Anatomical data from MRI was used to design a 3D model of the liver, lungs, and abdomen.
  • The phantom was manufactured using PolyJet 3D printing technology with acrylic plastic material.
  • The design incorporated features for lesion inserts and access to internal cavities.

Main Results:

  • The 3D-printed phantom material exhibited properties similar to PMMA, suitable for CT attenuation.
  • Initial SPECT/CT and PET/CT scans showed good agreement with anatomical references and volume measurements within 9%.
  • Quantitative analysis allowed for the calculation of absorbed doses in lesions and normal liver tissue.

Conclusions:

  • 3D printing offers a flexible and cost-efficient method for creating anthropomorphic phantoms.
  • This phantom serves as a valuable tool for evaluating quantitative imaging and dosimetry methodologies.
  • Optimized use of such phantoms can contribute to improved patient outcomes in SIRT.