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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Basal Lamina are the Specialized Form of ECM01:03

Basal Lamina are the Specialized Form of ECM

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The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
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Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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What is the Immune System?01:38

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Overview
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Membrane Domains01:18

Membrane Domains

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The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
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Related Experiment Video

Updated: Mar 16, 2026

Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis
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Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis

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Basement membranes and autoimmune diseases.

Mary H Foster1

  • 1Department of Medicine, Duke University Medical Center, Durham, NC, USA; Durham VA Medical Center, Durham, NC, USA.

Matrix Biology : Journal of the International Society for Matrix Biology
|August 7, 2016
PubMed
Summary

Autoimmune diseases often target basement membrane components like collagen and laminin, leading to organ damage. Understanding this autoimmunity is key to developing treatments for conditions such as glomerulonephritis and rheumatoid arthritis.

Keywords:
Anti-glomerular basement membraneAutoimmunityBasement membrane

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Area of Science:

  • Immunology
  • Pathology
  • Nephrology

Background:

  • Basement membranes are crucial structural components in many organs.
  • Autoimmune attacks on basement membranes cause diverse organ-specific diseases.
  • Collagen and laminin epitopes are frequent targets in autoimmune conditions.

Purpose of the Study:

  • To review major diseases associated with basement membrane autoreactivity.
  • To explore insights from patient and animal model studies on disease pathogenesis.
  • To focus on autoimmunity targeting glomerular basement membrane type IV.

Main Methods:

  • Literature review of autoimmune diseases targeting basement membranes.
  • Analysis of studies on patients and animal models of basement membrane autoimmunity.
  • In-depth examination of anti-glomerular basement membrane type IV autoimmunity.

Main Results:

  • Basement membrane components are implicated in kidney, lung, skin, and joint diseases.
  • Autoantibodies and T cells target collagen and laminin in conditions like Goodpasture's disease and rheumatoid arthritis.
  • Glomerular basement membrane type IV autoimmunity serves as a model for organ-specific autoimmune responses.

Conclusions:

  • Basement membrane autoreactivity is a significant factor in multiple autoimmune diseases.
  • Studies reveal the complexity of anti-basement membrane immunity.
  • Genetic and environmental factors contribute to susceptibility to these autoimmune conditions.