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Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
Assessment of Donation Potential After Circulatory Death as the First Step in Implementing and Running a Hospital
L Szemis1, M Kosieradzki2, A Chmura2
1Emergency Department, Medical University of Warsaw, Poland.
Insights
Poland
Area of Science:
- Medical Science
- Transplantation Medicine
- Public Health
Background:
- The potential for organ donation from circulatory death (DCD) donors in Poland remains unquantified.
- Establishing a quality organ harvesting system for DCD donors is a priority for hospitals.
- This study addresses the unknown DCD donor potential in a Polish hospital setting.
Purpose of the Study:
- To assess the potential for organ donation after circulatory death (DCD) through retrospective analysis of hospital deaths.
- To evaluate the feasibility of implementing DCD donation protocols in a large, multispecialty hospital in Warsaw.
Main Methods:
- Retrospective analysis of 718 deceased patient records from 2010-2014 at Hospital Infant Jesus, Warsaw.
- Classification of potential DCD donors based on established criteria (IIb category).
- Analysis of patient characteristics to identify disqualifying factors for kidney donation and transplantation.
Main Results:
- Out of 718 deaths, 664 (92%) had disqualifying factors for DCD donation, primarily age and comorbidities.
- Approximately 54.8% of deceased patients (n=54) did not present factors excluding them from DCD donation.
- This indicates a significant, previously unrecognized potential for DCD in this population.
Conclusions:
- The study demonstrates a viable potential for DCD donation in Warsaw, with an estimated 54 potential donations over four years.
- These findings support the development of a structured organ donation system and specific algorithms for DCD.
- Implementing DCD protocols can enhance organ availability for transplantation in Poland.
Background:
In Poland the potential for organ donation from donation after circulatory death (DCD) donors is not known. This assessment will allow the hospital to create a quality organ harvesting system from this group of donors.
Aims:
The aim of this study was to assess the DCD potential based on retrospective analysis of hospital deaths at Hospital Infant Jesus in Warsaw.
Methods:
Documentation of 718 deceased patients from 2010 to 2014 was analyzed. This population could be classified as potential DCD donors in IIb category. The deceased's characteristics were analyzed while undergoing the qualification process for DCD. The analysis was to confirm the presence or absence of factors disqualifying kidneys from donation and transplantation. Data from particular departments and from the entire hospital were analyzed.
Results:
The total number of deaths was 718. Excluding factors from the DCD donation process were found in 664 cases (92%), mainly age >60 and concomitant diseases. The rest of the patients (n = 54.8%) did not have factors that would exclude DCD donation. Group characteristics are given in detail.
Summary:
The attempt to measure donation potential was done at the Hospital of the Infant Jesus in Warsaw, a large, multispecialty hospital with intensive organ donation and transplantation programs. Results show a potential for DCD donation (54 potential donations over the last 4years), which allows us to create a quality system and algorithms for organ donation after circulation death.
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