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Published on: August 12, 2017
BICD1 and Chromosome 18 Polymorphisms Associated With Recipients' Telomere Length Affect Kidney Allograft Function
K Kłoda1, L Domański1, E Kwiatkowska1
1Clinical Department of Nephrology, Transplantology, and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
Recipient genetic factors influence kidney transplant success. Specific gene polymorphisms in BICD1 and chromosome 18 are linked to delayed graft function and long-term kidney function, highlighting their importance in transplantation outcomes.
Area of Science:
- Nephrology
- Genetics
- Transplantation Immunology
Background:
- Limited understanding of non-modifiable genetic factors influencing kidney allograft function.
- Investigating recipient genetic predispositions for improved transplant outcomes is crucial.
Purpose of the Study:
- To analyze associations between recipient genetic polymorphisms (rs2735940 hTERT, rs2630578 BICD1, rs7235755 chromosome 18) and kidney function post-transplantation.
Main Methods:
- Real-time polymerase chain reaction used to genotype 119 Polish kidney allograft recipients.
- Analysis focused on specific single nucleotide polymorphisms (SNPs) in hTERT, BICD1, and chromosome 18.
Main Results:
- rs7235755 (chromosome 18) polymorphism associated with delayed graft function (DGF); A allele increased DGF risk.
- rs2630578 (BICD1) polymorphism linked to elevated long-term creatinine levels; C allele associated with higher creatinine post-transplant.
Conclusions:
- Recipient genetic variations in BICD1 and chromosome 18, not hTERT, impact early and long-term kidney allograft function.
- Further genome-wide association studies are needed to elucidate these genetic associations in transplantation.
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