Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

2.8K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.8K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.4K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.4K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

705
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
705
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

650
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
650

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic characterization of humidity-induced perovskite/polyacrylonitrile composite nanofibers based on tilted fiber grating.

Optics express·2026
Same author

Development and internal validation of a multivariable prognostic prediction model in advanced breast cancer patients based on the SEER database.

Translational cancer research·2026
Same author

Surface Energy Modulation of NiO<sub><i>x</i></sub> through In Situ Click-Cross-Linked Networks for Air-Processed Flexible Blue Perovskite Light-Emitting Diodes.

The journal of physical chemistry. A·2026
Same author

Highly Aqueous Stability of Metal Oxides Encapsulated CsPbBr<sub>3</sub> Nanocrystals via A Generalized Core-Shell Engineering.

Small methods·2026
Same author

25-Year outcomes following the regionalization of three competing pediatric cardiac surgery programs.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Inhibition of Cyclophilin D Rescues Cardiac Function and Bioenergetic Defects Caused by Neonatal Hypoxia.

JACC. Basic to translational science·2026

Related Experiment Video

Updated: Mar 16, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.6K

Outcomes Using a Conservative Versus Liberal Red Blood Cell Transfusion Strategy in Infants Requiring Cardiac

Jill M Cholette1, Michael F Swartz2, Jeffrey Rubenstein1

  • 1Department of Pediatrics, University of Rochester, Rochester, New York.

The Annals of Thoracic Surgery
|August 7, 2016
PubMed
Summary
This summary is machine-generated.

A conservative red blood cell (RBC) transfusion strategy in infants after cardiac surgery is safe and effective. This approach, using lower hemoglobin thresholds, reduces transfusions without impacting clinical outcomes or oxygen delivery.

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
08:15

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

995

Related Experiment Videos

Last Updated: Mar 16, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.6K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
08:15

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

995

Area of Science:

  • Pediatric Cardiology
  • Transfusion Medicine
  • Critical Care Medicine

Background:

  • The optimal hemoglobin threshold for red blood cell (RBC) transfusions in infants following cardiac surgery remains unclear.
  • Current practice often involves transfusing RBCs to maintain high hemoglobin levels without clear clinical indications.
  • This study investigated a conservative RBC transfusion strategy to assess its impact on clinical outcomes and oxygen delivery.

Purpose of the Study:

  • To determine if a conservative postoperative RBC transfusion strategy in infants undergoing cardiac operations is associated with adverse clinical outcomes.
  • To compare oxygen delivery markers (lactate, arteriovenous oxygen difference) between conservative and liberal transfusion groups.
  • To evaluate the feasibility of managing infants with lower hemoglobin concentrations post-cardiac surgery.

Main Methods:

  • A randomized controlled trial involving infants (≤10 kg) undergoing biventricular repair or palliative cardiac operations.
  • Two groups were assigned: conservative (transfusion for hemoglobin <7.0 g/dL [biventricular] or <9.0 g/dL [palliative] plus clinical indication) and liberal (transfusion for hemoglobin <9.5 g/dL [biventricular] or <12 g/dL [palliative] regardless of indication).
  • Data on hemoglobin levels, RBC transfusion requirements, lactate, arteriovenous oxygen difference, and clinical outcomes were collected.

Main Results:

  • Infants in the conservative group had significantly lower daily hemoglobin concentrations for over 10 days postoperatively compared to the liberal group.
  • The conservative strategy resulted in a significantly lower percentage of patients requiring RBC transfusions, fewer transfusions, and a lower volume of transfusions.
  • Despite lower hemoglobin levels, there were no significant differences in lactate levels, arteriovenous oxygen difference, or clinical outcomes between the groups.

Conclusions:

  • A conservative RBC transfusion strategy is feasible and safe for infants undergoing cardiac operations.
  • Clinical indications should guide RBC transfusion decisions, even in this vulnerable pediatric population.
  • Further multicenter trials are warranted to confirm these findings, particularly in high-risk patient groups.