Implementation of Birth-Cohort Testing for Hepatitis C Virus

Area of Science:

• Public Health
• Hepatology
• Infectious Diseases

Background:

• Hepatitis C virus (HCV) infection impacts millions in the US.
• The 1945-1965 birth cohort is at higher risk for HCV.
• CDC recommends universal HCV antibody testing for this demographic.

Purpose of the Study:

• To share implementation experiences of three sites testing the 1945-1965 birth cohort.
• To evaluate interventions aimed at increasing birth-cohort HCV testing.
• To identify facilitators and barriers to implementing HCV screening recommendations.

Main Methods:

• Case study design involving three implementation sites.
• Qualitative analysis of project manager questionnaires on implementation experiences.
• Interventions included in-person recruitment, mail recruitment, and EHR prompts.

Main Results:

• Successful interventions increased HCV testing rates and case identification.
• Stakeholder buy-in was critical for intervention implementation and sustainability.
• Administrative barriers were more significant than anticipated; EHR interventions required technological support.

Conclusions:

• Despite challenges, birth-cohort HCV testing interventions are effective.
• Additional staffing and addressing administrative/technological hurdles are necessary.
• Future research should assess the cost-effectiveness of different HCV screening strategies.