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Updated: Mar 16, 2026
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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Entheseal involvement in systemic lupus erythematosus: are we missing something?
A Di Matteo1, I Satulu2, M Di Carlo1
11 Clinica Reumatologica, "C. Urbani" Hospital, Università Politecnica delle Marche, Jesi, Ancona, Italy.
Lupus
|August 7, 2016
Summary
Musculoskeletal ultrasound (MSUS) revealed enthesitis in 20% of systemic lupus erythematosus (SLE) patients, suggesting enthesis may be an overlooked target in SLE evaluation and warrants further research.
Area of Science:
- Rheumatology
- Medical Imaging
- Systemic Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) commonly affects musculoskeletal system.
- Musculoskeletal ultrasound (MSUS) shows potential for evaluating synovitis in SLE.
- Enthesis involvement is not traditionally considered in SLE pathology.
Observation:
- MSUS scanning of entheses was performed in 20 SLE patients.
- Four cases (20%) demonstrated unequivocal MSUS enthesitis.
- Three patients lacked predisposing factors for enthesopathy.
Findings:
- MSUS revealed significant grey-scale and power Doppler abnormalities at entheses, particularly the patellar tendon.
- Clinical signs of enthesitis were present in only one patient.
- MSUS detected subclinical enthesitis in SLE patients.
Implications:
- Enthesis may represent a previously unrecognized target in SLE.
- Findings suggest enthesitis should be considered in SLE clinical evaluation.
- Further research is needed to determine the prevalence and clinical significance of entheseal involvement in SLE.
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