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Progranulin is increased in human and murine lipodystrophy
Konstanze Miehle1, Thomas Ebert2, Susan Kralisch2
1Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany.
Diabetes Research and Clinical Practice
|August 7, 2016
Summary
Progranulin levels are elevated in lipodystrophy (LD) patients and correlate with C-reactive protein. Adipose tissue and muscle may contribute to increased progranulin in this condition.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Adipokine Research
Background:
- Lipodystrophies (LD) involve adipose tissue deficiency and adipokine dysregulation.
- Progranulin, an adipokine linked to inflammation and insulin resistance, has not been studied in LD.
Purpose of the Study:
- To investigate circulating progranulin levels in patients with lipodystrophy.
- To explore progranulin expression in an LD mouse model.
- To assess progranulin changes during metreleptin treatment in LD patients.
Main Methods:
- Measured serum progranulin in 37 LD patients and 37 controls.
- Examined progranulin mRNA in adipose tissue and muscle of LD mice.
- Monitored progranulin in 10 LD patients before and during metreleptin therapy.
Main Results:
- Progranulin was significantly higher in LD patients (82.9 μg/l) versus controls (73.6 μg/l).
- C-reactive protein (CRP) independently predicted higher progranulin levels.
- Progranulin mRNA was upregulated in adipose tissue and muscle of LD mice.
- Metreleptin treatment did not alter progranulin levels.
Conclusions:
- Serum progranulin is elevated in lipodystrophy patients.
- Progranulin elevation correlates positively with CRP.
- Adipose tissue depots and muscle are potential sources of increased progranulin in LD.
