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Related Experiment Video

Updated: Mar 16, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Disrupting the Grid Cells' Need for Speed.

Robin Hayman1, Neil Burgess1

  • 1UCL Institute of Cognitive Neuroscience, and UCL Institute of Neurology, University College London, 17 Queen Square, London WC1N 3AZ, UK.

Neuron
|August 7, 2016
PubMed
Summary

Researchers found two distinct speed signals in the rodent brain's medial entorhinal cortex. These signals were differently impacted by medial septum inactivation, providing key insights into grid cell firing models.

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • The medial entorhinal cortex (MEC) is crucial for spatial navigation.
  • Grid cells within the MEC exhibit firing patterns that encode spatial location.
  • Understanding the factors influencing grid cell firing is essential for modeling spatial cognition.

Purpose of the Study:

  • To investigate the presence and characteristics of speed signals in the rodent MEC.
  • To determine how inactivation of the medial septum affects these speed signals.
  • To constrain computational models of grid cell firing based on experimental findings.

Main Methods:

  • Electrophysiological recordings in rodent medial entorhinal cortex.
  • Pharmacological inactivation of the medial septum using muscimol.

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  • Analysis of neural firing patterns in relation to animal movement and septal manipulation.

    • Main Results:

    • Demonstration of at least two distinct speed signals within the MEC.
    • Differential effects of medial septum inactivation on these identified speed signals.
    • Evidence suggesting that speed information is processed distinctly within the MEC.

    Conclusions:

    • The findings highlight the complex neural mechanisms underlying spatial representation in the MEC.
    • Results provide critical data for refining computational models of grid cell function.
    • The medial septum plays a differential role in modulating speed-dependent inputs to the MEC.