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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Rethinking biologics in lupus nephritis

S Venuturupalli1

  • 1Cedars-Sinai Health System - Rheumatology, USA swamy.venuturupalli@gmail.com.

Lupus
|August 7, 2016
PubMed

Lupus nephritis (LN) is a chronic and devastating complication of systemic lupus erythematosus. Despite advances in our understanding of LN and the availability of effective therapies, LN remains a difficult clinical problem, and progression to end stage renal disease remains a significant challenge. Though the advent of biologics has revolutionized the treatment of many rheumatological conditions, and several clinical trials of biologics have been conducted in LN, the promise of biologics remains unfulfilled. The experience gained from these initial clinical trials can help tailor approaches in future clinical trials, and the lessons learned can be applied to find a cure for this condition.

Keywords:
Systemic lupus erythematosusbiologicsclinical trialslupus nephritisreview

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