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Brain sulfide levels in anaesthesia: a comparison with hydrogen sulfide intoxication
M W Warenycia1, R J Reiffenstein, L R Goodwin
1Department of Pharmacology, University of Alberta, Edmonton, Canada.
Toxicology Letters
|June 1, 1989
Abstract:
Although sublethal concentrations of hydrogen sulfide produce a state not unlike anaesthesia, measurement of rat brain sulfide levels by gas dialysis and IC with electrochemical detection after either 1.5 g/kg urethane or 42 mg/kg pentobarbital failed to demonstrate any changes as compared with endogenous brain sulfide levels of saline-injected controls. This suggests that the mechanisms underlying anaesthesia are not directly linked to endogenous cerebral sulfide levels.