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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Pulmonary involvement in systemic sclerosis.

Adriana Morales-Cárdenas1, Camila Pérez-Madrid1, Liliana Arias2

  • 1Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.

Autoimmunity Reviews
|August 8, 2016
PubMed
Summary

Systemic sclerosis (SSc) is an autoimmune disease affecting multiple organs, particularly the lungs, which are linked to mortality. This review details pulmonary involvement in SSc, focusing on imaging and pathology correlations.

Keywords:
PathologyPulmonary involvementRadiologySystemic sclerosisTomographyX-ray computed

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Area of Science:

  • Rheumatology
  • Pulmonology
  • Radiology

Background:

  • Systemic sclerosis (SSc) is a multi-systemic autoimmune disease impacting skin, lungs, and other organs.
  • Pulmonary disease in SSc significantly contributes to patient mortality.
  • Pathophysiology involves autoimmune cell activation and fibroblast hyperplasia, leading to excessive collagen production.

Purpose of the Study:

  • To provide a comprehensive review of pulmonary involvement in Systemic Sclerosis (SSc).
  • To highlight the correlations between radiologic findings and pathologic features of lung disease in SSc.

Main Methods:

  • Literature review focusing on pulmonary manifestations in Systemic Sclerosis.
  • Analysis of radiologic-pathologic correlations in SSc-related lung disease.

Main Results:

  • High-resolution computed tomography (HRCT) is a sensitive and specific method for diagnosing interstitial lung disease in SSc.
  • Radiologic findings on HRCT correlate with specific pathological changes in the lungs of SSc patients.

Conclusions:

  • Pulmonary involvement is a critical determinant of mortality in Systemic Sclerosis.
  • Understanding radiologic-pathologic correlations is essential for managing SSc-related lung disease.