Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic and redox adaptations of the corneal endothelium: From metabolic plasticity to therapeutic opportunities.

Redox biology·2026
Same author

Corneal stromal stem cell-derived extracellular vesicles inhibit corneal neovascularization.

Indian journal of ophthalmology·2026
Same author

Multimodal Imaging of the Corneal Endothelial Transition Zone Reveals Progenitor Cell Population.

Cells·2025
Same author

Biomechanical evaluation of porcine lens capsule with and without nucleus after capsulotomy - Finite element analysis.

Computer methods in biomechanics and biomedical engineering·2024
Same author

Regenerative Therapy for Corneal Scarring Disorders.

Biomedicines·2024
Same author

Neuropathic Corneal Pain: Tear Proteomic and Neuromediator Profiles, Imaging Features, and Clinical Manifestations.

American journal of ophthalmology·2024

Related Experiment Video

Updated: Mar 16, 2026

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
11:13

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

9.6K

Advances in corneal cell therapy.

Matthias Fuest1,2, Gary Hin-Fai Yam1,3, Gary Swee-Lim Peh1,3

  • 1Tissue Engineering & Stem Cell Group, Singapore Eye Research Institute, Singapore.

Regenerative Medicine
|August 9, 2016
PubMed
Summary
This summary is machine-generated.

Corneal integrity is vital for sight. This review explores stem cell and cultivated ocular cell therapies as promising alternatives to corneal transplantation due to donor shortages.

Keywords:
cell therapycorneastem cells

More Related Videos

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research
10:11

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Published on: October 27, 2023

1.6K
A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1
12:36

A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1

Published on: July 22, 2022

5.1K

Related Experiment Videos

Last Updated: Mar 16, 2026

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
11:13

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

9.6K
Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research
10:11

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Published on: October 27, 2023

1.6K
A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1
12:36

A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1

Published on: July 22, 2022

5.1K

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Corneal integrity is crucial for vision.
  • Corneal transplantation is the primary treatment for advanced corneal diseases.
  • A global shortage of donor corneal material necessitates alternative therapeutic strategies.

Purpose of the Study:

  • To review the latest advancements in primary ocular cell and stem cell research for corneal therapy.
  • To highlight the potential of cultivated ocular cells as an alternative to traditional transplantation.

Main Methods:

  • Review of current scientific literature on ocular cell and stem cell research.
  • Analysis of in vitro and animal model studies.
  • Examination of evolving clinical practices and trials.

Main Results:

  • Various stem cell populations can be induced to exhibit corneal cell characteristics.
  • In vitro propagation and implantation of primary corneal cells are rapidly advancing.
  • Clinical trials for corneal endothelial cells are underway, showing promise for cultivated cells.

Conclusions:

  • Cultivated ocular cells represent a promising future option for corneal therapy.
  • Further research and ethical considerations are needed before human application of stem cell-derived corneal therapies.
  • Advancements in cell-based therapies offer hope for overcoming donor material limitations in treating corneal diseases.