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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

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Advances in corneal cell therapy

Matthias Fuest1,2, Gary Hin-Fai Yam1,3, Gary Swee-Lim Peh1,3

  • 1Tissue Engineering & Stem Cell Group, Singapore Eye Research Institute, Singapore.

Regenerative Medicine
|August 9, 2016
PubMed

Insights

Corneal integrity is vital for sight. This review explores stem cell and cultivated ocular cell therapies as promising alternatives to corneal transplantation due to donor shortages.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Corneal integrity is crucial for vision.
  • Corneal transplantation is the primary treatment for advanced corneal diseases.
  • A global shortage of donor corneal material necessitates alternative therapeutic strategies.

Purpose of the Study:

  • To review the latest advancements in primary ocular cell and stem cell research for corneal therapy.
  • To highlight the potential of cultivated ocular cells as an alternative to traditional transplantation.

Main Methods:

  • Review of current scientific literature on ocular cell and stem cell research.
  • Analysis of in vitro and animal model studies.
  • Examination of evolving clinical practices and trials.

Main Results:

  • Various stem cell populations can be induced to exhibit corneal cell characteristics.
  • In vitro propagation and implantation of primary corneal cells are rapidly advancing.
  • Clinical trials for corneal endothelial cells are underway, showing promise for cultivated cells.

Conclusions:

  • Cultivated ocular cells represent a promising future option for corneal therapy.
  • Further research and ethical considerations are needed before human application of stem cell-derived corneal therapies.
  • Advancements in cell-based therapies offer hope for overcoming donor material limitations in treating corneal diseases.
Keywords:
cell therapycorneastem cells

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