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Updated: Mar 16, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Quantitative determination of activation energies in mechanochemical reactions
Franziska Fischer1, Klaus-Jürgen Wenzel2, Klaus Rademann1
1BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Str. 11, 12489 Berlin, Germany. franziska.emmerling@bam.de and Humboldt-Universität zu Berlin, B.-Taylor-Str. 2, 12489 Berlin, Germany.
Abstract:
Mechanochemical reactions often result in 100% yields of single products, making purifying procedures obsolete. Mechanochemistry is also a sustainable and eco-friendly method. The ever increasing interest in this method is contrasted by a lack in mechanistic understanding of the mechanochemical reactivity and selectivity. Recent in situ investigations provided direct insight into formation pathways. However, the currently available theories do not predict temperature T as an influential factor. Here, we report the first determination of an apparent activation energy for a mechanochemical reaction. In a temperature-dependent in situ study the cocrystallisation of ibuprofen and nicotinamide was investigated as a model system. These experiments provide a pivotal step towards a comprehensive understanding of milling reaction mechanisms.
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