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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

14.0K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
14.0K
Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

8.5K
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
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Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
7.8K
Overview of the Skull01:08

Overview of the Skull

8.7K
The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the brain case, or cranial vault. The facial bones underlie the facial structures, form the nasal cavity, enclose the eyeballs, and support the teeth of the upper and lower jaws.
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
8.7K
Nondisjunction01:21

Nondisjunction

5.6K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
5.6K
Nondisjunction01:29

Nondisjunction

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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Related Experiment Video

Updated: Mar 16, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

365

[Non syndromic craniosynostosis].

Y Bennis1, A Wolber2, M Vinchon3

  • 1Service de chirurgie plastique reconstructrice et esthétique, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille, France.

Annales De Chirurgie Plastique Et Esthetique
|August 9, 2016
PubMed
Summary
This summary is machine-generated.

Craniosynostosis, a premature fusion of skull sutures, affects about 1 in 2000 births. Early surgical intervention is recommended before age one to prevent developmental issues and social impact.

Keywords:
Bicoronal synostosisBrachycéphalieCraniosténoses non syndromiquesEpidemiologyMetopic synostosisNon syndromic craniosynostosisOxycephalyOxycéphaliePlagiocéphalieSagittal synososisScaphocéphalieSurgical treatmentTraitement chirurgicalTrigonocéphalieUnicoronal synostosisÉpidémiologie

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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Area of Science:

  • Pediatric Surgery
  • Developmental Biology
  • Craniofacial Surgery

Background:

  • Craniosynostosis involves premature fusion of cranial sutures, impacting skull development.
  • Non-syndromic craniosynostosis (NSC) is the most common form, classified by affected sutures and resulting deformities.
  • The exact causes of premature suture fusion remain unclear, despite a multifactorial origin.

Purpose of the Study:

  • To outline the classification, risks, and management of craniosynostosis.
  • To emphasize the importance of multidisciplinary care and timely surgical intervention.
  • To highlight the need for long-term follow-up to monitor for recurrence or progression.

Main Methods:

  • Classification based on synostotic sutures and cranial deformation (e.g., scaphocephaly, trigonocephaly).
  • Assessment of risks including increased intracranial pressure and developmental impacts.
  • Multidisciplinary team approach for treatment strategy development.

Main Results:

  • Craniosynostosis can lead to increased intracranial pressure, affecting psychomotor development, vision, and respiration.
  • Emergency surgery may be required for severe cases.
  • Surgical intervention is ideally performed before one year of age, prioritizing morphological outcomes.

Conclusions:

  • Craniosynostosis requires a tailored treatment strategy based on age, type, and severity.
  • Early surgical correction is crucial for optimal outcomes and to prevent social harm.
  • Ongoing monitoring throughout childhood is essential to detect complications or disease progression.