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The relationship between total urinary testosterone and renal calculi
C H van Aswegen1, P Hurter, C A van der Merwe
1Department of Urology, H. F. Verwoerd Hospital, Pretoria, Republic of South Africa.
Urological Research
|January 1, 1989
Summary
Lower urinary testosterone levels are linked to kidney stones in men. This study found reduced testosterone in stone patients and a correlation with urokinase activity, suggesting a role in urolithiasis pathogenesis.
Area of Science:
- Urology
- Endocrinology
- Nephrology
Background:
- Urolithiasis (kidney stones) risk is influenced by age and sex.
- Testosterone levels naturally decline with age, particularly in elderly individuals.
Purpose of the Study:
- To investigate the relationship between urinary testosterone concentrations and the presence of renal stones.
- To explore the potential role of testosterone in the multifactorial disease of urolithiasis.
Main Methods:
- Radioimmunoassay was used to measure total urinary testosterone concentrations.
- Comparison of testosterone levels between patients with and without kidney stones within matched age groups.
- Correlation analysis between urinary testosterone and urinary urokinase activity.
Main Results:
- Urinary total testosterone concentrations were significantly lower in patients with kidney stones compared to healthy individuals.
- A positive correlation was observed between total urinary testosterone concentrations and urinary urokinase activity.
- Urinary testosterone levels demonstrated an age-dependent decrease.
Conclusions:
- Reduced urinary testosterone levels may be a contributing factor in the development of kidney stones.
- Testosterone's influence on urokinase activity suggests a potential mechanism in urolithiasis pathogenesis.
- Urinary testosterone warrants further investigation as a biomarker and potential therapeutic target in urolithiasis.