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Specific immunotherapy ameliorates ulcerative colitis.

Min Cai1, Lu Zeng2, Lin-Jing Li3

  • 1Department of Gastroenterology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|August 9, 2016
PubMed
Summary
This summary is machine-generated.

Specific immunotherapy (SIT) combined with Clostridium butyricum (CB) probiotics effectively suppressed ulcerative colitis (UC) symptoms in patients with food allergies. Combination therapy significantly improved clinical outcomes compared to either treatment alone.

Keywords:
B lymphocyteFood allergyImmunoglobulin EInflammationIntestine

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Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Inflammatory bowel disease (IBD) pathogenesis involves hypersensitivity to allergens.
  • Ulcerative colitis (UC) is a form of IBD.
  • Food allergies may contribute to UC development.

Purpose of the Study:

  • To investigate the efficacy of specific immunotherapy (SIT) in IBD patients.
  • To evaluate the combined effect of SIT and Clostridium butyricum (CB) in UC patients with food allergies.

Main Methods:

  • Recruited UC patients diagnosed with food allergy via skin prick tests and serum specific IgE.
  • Administered treatment with SIT and CB capsules.
  • Assessed clinical symptoms using truncated Mayo scores and medication scores.

Main Results:

  • Combined SIT and CB treatment markedly suppressed UC clinical symptoms.
  • Reduced serum levels of specific IgE, IL-4, and TNF-α observed.
  • SIT or CB monotherapy showed no significant clinical improvement.

Conclusions:

  • Specific immunotherapy (SIT) combined with butyrate-producing probiotics (CB) ameliorates UC in patients with food allergies.
  • Combination therapy offers a potential treatment strategy for this patient subgroup.