[Fibrin-stabilizing factor and its significance in the surgical treatment of patients with obstructive jaundice]

The fibrin-stabilizing factor (XIII factor of the hemostasis system) was studied in 101 patients with unresolved mechanical jaundice. It was first shown that this disease is characterized by a statistically significant decrease of the FSF to 56-68%. The decrease of the XIII factor is prognostically unfavourable and points to the development of hepatic insufficiency. The experience has shown that in critical patients with the content of FSF lower than 30% it is expedient to perform decompressive procedures such as cholecystostomy, percutaneous transhepatic cholangiostomy, endoscopic papillotomy etc. as well as transfusion of fresh frozen plasma and hemosorption if there is no contraindications. In patients with FSF lower than 50% before operation it is sufficient to perform hemosorption and transfusion of fresh frozen plasma.