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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

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Special considerations for the management of pediatric acute respiratory distress syndrome

Joel Kian Boon Lim1, Jan Hau Lee2,3, Ira M Cheifetz4

  • 1a Department of Pediatrics , KK Women's and Children's Hospital , Singapore.

Expert Review of Respiratory Medicine
|August 9, 2016
PubMed

Insights

Pediatric acute respiratory distress syndrome (ARDS) presents diagnostic and treatment challenges. Current evidence is insufficient to routinely use high-frequency oscillatory ventilation or corticosteroids in children with ARDS.

Area of Science:

  • Pediatric critical care medicine
  • Respiratory medicine
  • Pediatric pulmonology

Background:

  • Pediatric acute respiratory distress syndrome (ARDS) poses significant mortality and morbidity challenges.
  • Limited data exist for guiding the identification and management of pediatric ARDS.

Purpose of the Study:

  • To review recent advancements and expert commentary on pediatric ARDS.
  • To discuss key areas including novel definitions, high-frequency oscillatory ventilation, corticosteroids, and functional outcomes.

Main Methods:

  • Literature search conducted on PubMed, ClinicalKey, and Google Scholar.
  • Utilized medical subject heading terms and text words related to acute lung injury and ARDS.

Main Results:

  • A new pediatric-specific ARDS definition requires validation for diagnostic and risk stratification efficacy.
  • Insufficient evidence currently supports routine use of high-frequency oscillatory ventilation or corticosteroids in pediatric ARDS.
  • Further research is needed to understand the impact of pediatric ARDS on long-term functional outcomes.

Conclusions:

  • The proposed pediatric ARDS definition needs further validation.
  • Current evidence does not support routine use of specific ventilation strategies or corticosteroids.
  • Long-term functional outcomes in pediatric ARDS require additional investigation.
Abstract

Keywords:
Acute respiratory distress syndromechildrencorticosteroidsdefinitionhigh frequency oscillatory ventilationoutcomespediatric

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