Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Competition02:34

Competition

25.3K
When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
25.3K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

4.0K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
4.0K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.2K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.2K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

3.2K
3.2K
Overview of Cell Signaling01:23

Overview of Cell Signaling

25.7K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
25.7K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

8.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of cardiac regeneration capacity between zebrafish and medaka reveals a regenerative response in both teleost species.

NPJ Regenerative medicine·2026
Same author

Mitochondria directly interact with the nuclear pore complex.

Nature·2026
Same author

Pro-regenerative fingerprints identified in a sub-population of adult mouse cardiomyocytes by integrative single-cell proteomics.

Genome biology·2026
Same author

Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation.

The Journal of biological chemistry·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs.

Nature structural & molecular biology·2026

Related Experiment Video

Updated: Mar 16, 2026

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
06:45

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains

Published on: January 18, 2014

9.1K

Cell Competition: Mechanisms and Physiological Roles.

Cristina Clavería1, Miguel Torres1

  • 1Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain;

Annual Review of Cell and Developmental Biology
|August 9, 2016
PubMed
Summary
This summary is machine-generated.

Cell competition, where neighboring cells compare properties to eliminate weaker ones, is crucial for tissue health and development. This process, triggered by metabolic or polarity changes, impacts homeostasis and can influence tumor suppression or promotion.

Keywords:
apoptosiscancercell fitnessproliferationregenerationtissue quality control

More Related Videos

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

15.9K
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

16.0K

Related Experiment Videos

Last Updated: Mar 16, 2026

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
06:45

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains

Published on: January 18, 2014

9.1K
Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

15.9K
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

16.0K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Genetics

Background:

  • Cell competition is a fundamental biological process involving non-autonomous sensing of intrinsic cellular properties between neighboring cells.
  • This interaction leads to the selective elimination of one cell population, a phenomenon first observed in Drosophila epithelia.
  • Recent advances have elucidated mechanisms, universality, and physiological relevance, particularly concerning metabolic status and epithelial polarity.

Purpose of the Study:

  • To review and synthesize current knowledge on cell competition mechanisms.
  • To highlight the roles of metabolic status and epithelial apico-basal polarity as key triggers.
  • To discuss the implications of cell competition in tissue homeostasis, repair, and its dual role in cancer.

Main Methods:

  • Literature review and synthesis of molecular and cellular analyses.
  • Analysis of studies focusing on Drosophila and other model systems.
  • Integration of findings on genetic and cellular pathways involved.

Main Results:

  • Cell competition is triggered primarily by alterations in cellular metabolic status and epithelial apico-basal polarity.
  • This process is vital for tissue quality control, homeostasis, and repair in developing and adult organisms.
  • Cell competition can act as either a tumor-suppressing or tumor-promoting mechanism depending on the biological context.

Conclusions:

  • Cell competition is a conserved mechanism with significant roles in multicellular organisms.
  • Understanding cell competition offers insights into developmental processes and disease pathologies.
  • Further research into less characterized pathways could reveal new therapeutic targets.