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Abnormal auditory pattern perception in schizophrenia.

Sarah M Haigh1, Brian A Coffman1, Timothy K Murphy1

  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Avenue, Pittsburgh, PA 15213, United States.

Schizophrenia Research
|August 10, 2016
PubMed
Summary
This summary is machine-generated.

Individuals with schizophrenia have impaired auditory deviance detection, shown by reduced mismatch negativity (MMN) responses to simple and complex sound changes. This deficit, particularly in later processing stages, may contribute to cognitive and social impairments in schizophrenia.

Keywords:
Complex-pattern deviantMismatch negativityPerceptual groupingSchizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Auditory Perception

Background:

  • Mismatch negativity (MMN) reflects auditory sensory memory and deviance detection.
  • Reduced MMN in schizophrenia suggests deficits in early auditory processing.
  • MMN abnormalities may contribute to cognitive and social deficits in schizophrenia.

Purpose of the Study:

  • To investigate auditory deviance detection using simple and complex MMN in schizophrenia.
  • To identify specific temporal processing deficits in schizophrenia.
  • To explore the relationship between MMN abnormalities and clinical symptoms in schizophrenia.

Main Methods:

  • Recorded MMN to simple pitch and duration deviants in 27 schizophrenia (Sz) patients and 27 healthy controls (HC).
  • Recorded MMN to complex pattern deviants (an extra tone in a sequence) in Sz and HC.
  • Analyzed MMN amplitude, latency, and topography, correlating with negative symptom measures.

Main Results:

  • Schizophrenia patients showed reduced simple pitch MMN (~110ms) and duration MMN (~170ms) compared to controls.
  • A late complex MMN (~400ms), likely generated in the anterior temporal cortex, was significantly reduced in schizophrenia.
  • An earlier complex MMN (~150ms) did not differ between groups.

Conclusions:

  • Schizophrenia is associated with deficits in both early and later stages of auditory deviance processing.
  • The blunted late complex MMN in schizophrenia suggests impaired higher-order auditory perception.
  • These auditory processing deficits may exacerbate cognitive and social impairments in schizophrenia.