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Updated: Mar 16, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
Genetics of Male Infertility
Filipe Tenorio Lira Neto1, Phil Vu Bach1, Bobby Baback Najari1
1Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Institute of Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA.
Abstract:
While 7 % of the men are infertile, currently, a genetic etiology is identified in less than 25 % of those men, and 30 % of the infertile men lack a definitive diagnosis, falling in the "idiopathic infertility" category. Advances in genetics and epigenetics have led to several proposed mechanisms for male infertility. These advances may result in new diagnostic tools, treatment approaches, and better counseling with regard to treatment options and prognosis. In this review, we focus on clinical aspects of male infertility and the role of genetics in elucidating etiologies and the potential of treatments.
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