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Pharmaceutical Approval Update.

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    P & T : a Peer-Reviewed Journal for Formulary Management
    |August 10, 2016
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    This summary is machine-generated.

    Three new treatments show promise: Venetoclax for chronic lymphocytic leukemia, riboflavin solutions for keratoconus, and pimavanserin for Parkinson

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    Area of Science:

    • Pharmacology and Therapeutics
    • Ophthalmology
    • Neurology

    Background:

    • Chronic lymphocytic leukemia (CLL) remains a significant hematologic malignancy.
    • Progressive keratoconus poses a risk to vision and requires effective interventions.
    • Parkinson's disease psychosis (PDP) is a challenging neuropsychiatric complication.

    Purpose of the Study:

    • To review the efficacy and safety of Venetoclax for CLL.
    • To evaluate riboflavin 5'-phosphate solutions for treating progressive keratoconus.
    • To assess the utility of pimavanserin in managing PDP.

    Main Methods:

    • Review of clinical trial data for Venetoclax in CLL.
    • Analysis of studies on riboflavin 5'-phosphate solutions in keratoconus.
    • Examination of clinical evidence for pimavanserin in PDP.

    Main Results:

    • Venetoclax demonstrates significant response rates in CLL patients.
    • Riboflavin treatments show potential in halting keratoconus progression.
    • Pimavanserin effectively reduces psychotic symptoms in Parkinson's disease.

    Conclusions:

    • Venetoclax offers a new therapeutic option for chronic lymphocytic leukemia.
    • Riboflavin 5'-phosphate solutions represent a novel approach for progressive keratoconus.
    • Pimavanserin provides a valuable treatment for Parkinson's disease psychosis.