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Related Concept Videos

Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Related Experiment Video

Updated: Mar 16, 2026

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
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Hedgehog Signalling in the Embryonic Mouse Thymus.

Alessandro Barbarulo1, Ching-In Lau1, Konstantinos Mengrelis1

  • 1Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.

Journal of Developmental Biology
|August 10, 2016
PubMed
Summary

The Hedgehog signaling pathway is crucial for T cell development and thymic epithelial cell (TEC) development in the embryonic mouse thymus. This review explores its role in T cell fate specification and thymocyte-TEC interactions.

Keywords:
Gli1Gli2Gli3HedgehogIhhShhT cell developmentthymic epithelial cell (TEC)thymus

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Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
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Area of Science:

  • Immunology
  • Developmental Biology
  • Molecular Biology

Background:

  • The thymus is a primary lymphoid organ essential for T cell maturation.
  • T cell development involves intricate processes of fate specification and differentiation.
  • Thymic epithelial cells (TECs) play a critical role in supporting T cell development.

Purpose of the Study:

  • To review the function of the Hedgehog signaling pathway in the embryonic mouse thymus.
  • To elucidate the pathway's role in T cell development and TEC differentiation.
  • To examine the cross-talk between thymocytes and TECs mediated by Hedgehog signaling.

Main Methods:

  • Literature review of studies on Hedgehog signaling in thymic development.
  • Analysis of research focusing on the embryonic mouse thymus during late gestation.
  • Synthesis of data on molecular mechanisms and cellular interactions.

Main Results:

  • Hedgehog signaling is implicated in both T cell progenitor differentiation and TEC development.
  • The pathway influences the thymic microenvironment necessary for T cell maturation.
  • Cross-talk between thymocytes and TECs is modulated by Hedgehog signaling.

Conclusions:

  • The Hedgehog pathway is a key regulator of T cell development and thymic organogenesis.
  • Understanding this pathway is vital for comprehending T cell immunity and potential therapeutic interventions.
  • Further research into thymocyte-TEC interactions mediated by Hedgehog signaling is warranted.