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A Therapeutic Effects of Atorvastatin on Genetic Damage in Coronary Artery Disease

Kishore Kumar Gundapaneni1, Nivas Shyamala1, Rajesh Kumar Galimudi2

  • 1Senior Research Fellow, Department of Genetics, Osmania University , Hyderabad, Telangana, India .

Journal of Clinical and Diagnostic Research : JCDR
|August 10, 2016
PubMed

Insights

Atorvastatin treatment significantly reduced lipid profiles and DNA damage in patients with Coronary Artery Disease (CAD). This suggests atorvastatin may help reverse these markers in CAD patients.

Area of Science:

  • Cardiology
  • Pharmacology
  • Genetics

Background:

  • Coronary Artery Disease (CAD) is a leading cause of death globally, characterized by plaque buildup in arteries.
  • Statins, like atorvastatin, are crucial for managing hypercholesterolemia and preventing cardiovascular events.
  • Limited data exists on statin effects on DNA damage in coronary atherosclerosis patients.

Purpose of the Study:

  • To assess the efficacy of atorvastatin in improving lipid profiles.
  • To evaluate the impact of atorvastatin on DNA damage markers in CAD patients.

Main Methods:

  • An observational study involving 180 CAD patients.
  • Atorvastatin was administered, with blood samples collected pre-treatment and after 6 months.
  • Lipid profiles and DNA damage were compared between patients and 200 healthy controls.

Main Results:

  • CAD patients exhibited significantly higher lipid profiles and DNA damage before atorvastatin therapy (p < 0.01).
  • A significant reduction in both lipid profiles and DNA damage was observed after 6 months of atorvastatin treatment.
  • These markers in treated patients more closely resembled those of healthy controls.

Conclusions:

  • Atorvastatin therapy demonstrates efficacy in improving lipid profiles in CAD patients.
  • The study suggests atorvastatin may contribute to the regression of DNA damage in individuals with coronary atherosclerosis.
  • Atorvastatin shows potential as a therapeutic agent for mitigating both lipid abnormalities and genetic damage in CAD.
Abstract

Keywords:
Comet assayLipid profileReactive oxygen species

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