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Evaluation of Autonomic Dysfunction in Obese and Non-Obese Hypertensive Subjects

Amjad Ali1, Jyoti Ganai2, Shobitha Muthukrishnan3

  • 1Physiotherapist, Charak Palika Hospital, NDMC , New Delhi, India .

Journal of Clinical and Diagnostic Research : JCDR
|August 10, 2016
PubMed

Insights

Obesity is linked to hypertension, but this study found no significant differences in cardiac autonomic function between obese and non-obese hypertensive patients. Further research is needed to explore this relationship.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Hypertension Research

Background:

  • Obesity, particularly visceral obesity, is a known risk factor for hypertension and cardiovascular disease.
  • Obesity is estimated to contribute to at least two-thirds of hypertension prevalence.
  • Hypertensive individuals often exhibit impaired cardiac autonomic function.

Purpose of the Study:

  • To investigate the specific impact of obesity on cardiac autonomic dysfunction in patients with hypertension.
  • To determine if obesity exacerbates autonomic dysfunction in hypertensive individuals.

Main Methods:

  • A comparative study involving 45 hypertensive subjects (ages 35-60).
  • Subjects were categorized into non-obese (n=30) and obese (BMI ≥30kg/m², n=15) groups.
  • Cardiac autonomic function was evaluated using heart rate response to standing (30:15 ratio), standing-to-lying ratio (S/L ratio), blood pressure response to standing, and the Cold Pressor Test (CPT).

Main Results:

  • No statistically significant differences were observed in any of the cardiac autonomic function tests between the obese and non-obese hypertensive groups (p > 0.05).

Conclusions:

  • Obesity does not appear to significantly alter cardiac autonomic function responses in hypertensive individuals.
  • The findings suggest that obesity's role in hypertension may not be mediated through significant changes in cardiac autonomic function as measured in this study.
Abstract

Keywords:
Cardiovascular functionHeart rate variabilityHypertensionObesitySympathovagal imbalance

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