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Related Experiment Video

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Test Tube Tooth: The Next Big Thing.

Preeti Yadav1, Mohammed Tahir2, Harsh Yadav3

  • 1Prosthodontics, Crown & Bridge & Implantology, Private Practitioner , Gurgaon, Haryana, India .

Journal of Clinical and Diagnostic Research : JCDR
|August 10, 2016
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Summary

Humans cannot regenerate teeth like some animals. This review explores tissue engineering strategies to bioengineer a third set of natural teeth, aiming to replicate natural tooth properties.

Keywords:
BioengineeringOdontogenesisRegenerationStem cells

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Developmental Biology

Background:

  • Humans lack natural tooth regeneration capabilities, unlike certain vertebrates and fish.
  • Current tooth replacement methods include dentures, prosthetics, and implants, but regenerating natural teeth remains an ideal goal.
  • Tissue engineering offers a promising avenue for bioengineering dental tissues and entire teeth.

Purpose of the Study:

  • To review the fundamental processes of tooth formation (odontogenesis).
  • To summarize the advancements in the bioengineering of whole teeth.
  • To highlight the challenges and potential of creating bioengineered teeth with natural properties.

Main Methods:

  • Review of existing literature on tooth development and regeneration.
  • Analysis of current tissue engineering techniques for dental applications.
  • Examination of studies focused on biofabricating dental tissues and whole teeth.

Main Results:

  • Detailed overview of the stages and cellular mechanisms in natural tooth organogenesis.
  • Compilation of progress in bioengineering approaches, including cell sourcing and scaffold development.
  • Identification of key biological, mechanical, and physical properties required for functional bioengineered teeth.

Conclusions:

  • Achieving whole tooth bioengineering requires addressing all relevant cells and tissues involved in tooth formation, maintenance, and repair.
  • Significant progress has been made in understanding odontogenesis and applying tissue engineering principles to dental regeneration.
  • The ultimate goal is to develop bioengineered teeth that are biologically, mechanically, and physically comparable to natural teeth.