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Arterial and Ventricular Elastance and Ventriculo-arterial Coupling in Asthmatic Children

Esra Akyuz Ozkan1, Hashem E Khosroshahi2, Mahmut Kilic3

  • 1Department of Pediatrics, Bozok University Medical Faculty, Yozgat, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|August 10, 2016
PubMed

Insights

Asthmatic children exhibit higher arterial elastance and ventriculo-arterial coupling (VAC) compared to healthy children, indicating less efficient cardiovascular function despite no difference in ventricular elastance. Inhaled corticosteroids may contribute to these findings.

Area of Science:

  • Pediatric Cardiology
  • Respiratory Medicine
  • Cardiovascular Physiology

Background:

  • Asthma affects children's cardiovascular system.
  • Ventriculo-arterial coupling (VAC) assesses heart-artery interaction.
  • Pulmonary function tests (PFTs) measure lung capacity.

Purpose of the Study:

  • Compare arterial and ventricular elastance and VAC in asthmatic vs. healthy children.
  • Correlate these parameters with PFTs in asthmatic children.

Main Methods:

  • Cross-sectional analytical study.
  • Transthoracic and Doppler echocardiography.
  • Pulmonary function tests in 40 asthmatic and 97 healthy children (aged 7-12).

Main Results:

  • Asthmatic children had higher arterial elastance (Ea/BSA) and VAC (p<0.001) than controls.
  • No significant difference in end-systolic ventricular elastance (Ees(sb)/BSA).
  • No correlation found between Ea, Ees(sb), VAC, and PFTs.

Conclusions:

  • Asthma is associated with increased arterial elastance and VAC, potentially due to inhaled corticosteroids.
  • Higher VAC in asthmatics suggests less efficient cardiovascular function.
  • Inhaled corticosteroids may offer protective cardiovascular effects.
Abstract

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