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Related Experiment Videos

The Wessex Growth Study: first report.

L Voss1, J Walker, H Lunt

  • 1Department of Paediatrics, General Hospital, Southampton, UK.

Acta Paediatrica Scandinavica. Supplement
|January 1, 1989
PubMed
Summary

The Wessex Growth Study found that many short children, even without underlying pathology, exhibited delayed bone age or low birth weight. Growth rates were slower than controls, but most fell within the normal range.

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Area of Science:

  • Pediatric Endocrinology
  • Growth and Development Studies
  • Longitudinal Cohort Research

Background:

  • The Wessex Growth Study is a community-based longitudinal survey assessing short children.
  • Screening identified a low prevalence (1.3%) of children at or below the 3rd height percentile, indicating a secular trend and need for updated charts.
  • The study focused on apparently normal short children after excluding those with organic pathology or from ethnic minorities.

Purpose of the Study:

  • To evaluate growth patterns and characteristics of short children within a community setting.
  • To compare growth parameters between short children and their sex- and age-matched normal controls.
  • To identify factors potentially contributing to short stature in apparently healthy children.

Main Methods:

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  • Recruitment of two cohorts (1985-86 and 1986-87) of new school entrants in two Wessex Health Districts.
  • Inclusion of 84 short children (cohort I) after exclusions, matched with normal controls from the same school class.
  • Assessment of bone age, parental height correction, birth weight, and serial height velocity measurements (6 and 12 months).

Main Results:

  • 42% of short children had delayed bone age; 34% remained below the 3rd percentile after parental height correction.
  • 44% of the short cohort had low birth weight.
  • Mean 12-month height velocity SDS was -0.45 for short children (33rd percentile) versus +0.25 for controls (60th percentile); 38% of short children had height velocity below the 25th percentile.

Conclusions:

  • A significant proportion of apparently normal short children exhibit factors like delayed bone age, low birth weight, and slower growth velocity.
  • While growth velocity was slower as a group, most short children's height velocity fell within the control range.
  • Findings highlight the heterogeneity of short stature and the need for comprehensive assessment beyond simple height percentiles.