Related Experiment Video
Updated: Mar 16, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
Current Status of Immunotherapy Treatments for Pancreatic Cancer
Cristina Jimenez-Luna1, Jose Prados, Raul Ortiz
1*Institute of Biopathology and Regenerative Medicine (IBIMER) ‡Department of Biochemistry and Molecular Biology I, Universidad de Granada, Granada †Department of Health Sciences, Universidad de Jaen, Jaen, Spain.
Abstract:
Pancreatic cancer (PC) is a lethal disease representing the seventh most frequent cause of death from cancer worldwide. Resistance of pancreatic tumors to current treatments leads to disappointing survival rates, and more specific and effective therapies are urgently needed. In recent years, immunotherapy has been proposed as a promising approach to the treatment of PC, and encouraging results have been published by various preclinical and clinical studies. This review provides an overview of the latest developments in the immunotherapeutic treatment of PC and summarizes the most recent and important clinical trials.
Insights
Pancreatic cancer (PC) remains a deadly disease with poor survival rates. Immunotherapy offers a promising new avenue for treatment, with ongoing research and clinical trials showing encouraging results for patients.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Pancreatic cancer (PC) is a leading cause of cancer mortality globally.
- Tumor resistance to existing therapies results in poor patient survival rates.
- Novel and effective treatment strategies for PC are critically needed.
Purpose of the Study:
- To review recent advancements in immunotherapy for pancreatic cancer.
- To summarize key findings from preclinical and clinical studies.
- To provide an overview of current and emerging immunotherapeutic approaches for PC treatment.
Main Methods:
- Literature review of preclinical research.
- Analysis of data from recent clinical trials.
- Synthesis of current knowledge on pancreatic cancer immunotherapy.
Main Results:
- Immunotherapy has emerged as a promising treatment modality for PC.
- Encouraging results have been reported in various preclinical and clinical investigations.
- Ongoing studies are exploring novel immunotherapeutic strategies for PC.
Conclusions:
- Immunotherapy holds significant potential for improving outcomes in pancreatic cancer.
- Further research and clinical trials are essential to optimize immunotherapeutic regimens.
- This review highlights the evolving landscape of PC treatment through immunotherapy.
Related Concept Videos
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistant Cancers
Chronic Pancreatitis II: Collaborative Care
Assessment:
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

