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Updated: Mar 16, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Published on: August 2, 2018
Regulation of myogenesis by environmental hypoxia
Michèle Beaudry1, Magdalena Hidalgo2, Thierry Launay3
1Université Paris13 Sorbonne Paris Cité, EA2363, UFR-SMBH, Laboratoire Hypoxie et poumons, Bobigny 93017, Cedex, France mbeaudry@yahoo.fr thierry.darribere@upmc.fr.
Abstract:
In aerobic organisms, oxygen is a critical factor for tissue and organ morphogenesis from embryonic development throughout the adult life. It regulates various intracellular pathways involved in cellular metabolism, proliferation, cell survival and fate. Organisms or tissues rapidly respond to changes in oxygen availability by activating complex signalling networks, which culminate in the control of mRNA translation and/or gene expression. This Commentary presents the effects of hypoxia during embryonic development, myoblasts and satellite cell proliferation and differentiation in vertebrates. We also outline the relationship between Notch, Wnt and growth factor signalling pathways, as well as the post-transcriptional regulation of myogenesis under conditions of hypoxia.
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