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Updated: Mar 16, 2026

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Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
Published on: October 6, 2022
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Binding-responsive catalysis of Taq DNA polymerase for the sensitive and selective detection of cell-surface proteins
Zhuxin Wang1, Yifei Li2, Peng Han1
1Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, China. conezimint@shu.edu.cn.
Abstract:
Here we develop a new method for the sensitive and selective detection of cell-surface proteins with an aptamer probe designed for binding-responsive catalysis of Taq DNA polymerase. Taking the biotin receptor as a model, the method allows the detection of target protein on surfaces of different types of cancer cells.

