Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation
Hyun-Jae Jang1, Hyun-Mee Oh2, Joo Tae Hwang2
1Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea; College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea.
Abstract:
Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.

