Effective axillary malodour reduction by polyquaternium-16-containing deodorants

Area of Science:

• Dermatology
• Microbiology
• Cosmetic Science

Background:

• Axillary malodour is a common concern addressed by topical deodorants.
• There is a continuous demand for effective and safe deodorant actives.
• Polymeric quaternary ammonium compounds (PQ-16) are investigated as potential antimicrobial agents.

Purpose of the Study:

• To evaluate the antimicrobial effectiveness of a novel polymeric quaternary ammonium compound (PQ-16) in a roll-on deodorant formulation.
• To compare the efficacy of the PQ-16 deodorant against a commercial benchmark and a control formulation.
• To assess the impact on axillary microbial growth and malodour intensity.

Main Methods:

• In vivo microbiological assessment of bacterial counts.
• Comparison of PQ-16 deodorant (DEO1) against a commercial deodorant (DEO2) and an aluminum chlorohydrate control (DEO3).
• Sensory evaluation of axillary malodour by a trained panel at 24 and 48 hours post-application.

Main Results:

• DEO1 significantly reduced bacterial counts compared to DEO2 at all time points.
• Malodour intensity was significantly lower with DEO1 versus DEO2 at 24 and 48 hours.
• DEO1 showed comparable results to DEO3 in bacterial counts and malodour at 48 hours.

Conclusions:

• Polyquaternium-16 (PQ-16) is a highly effective deodorant active ingredient.
• The PQ-16 roll-on formulation demonstrated significant reduction in axillary malodour and bacteria.
• PQ-16 offers an innovative, skin-friendly alternative for deodorant applications.