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Related Experiment Videos

Trace element status in multiple sclerosis.

D K Smith1, E B Feldman, D S Feldman

  • 1Department of Medicine, Medical College of Georgia, Augusta 30912.

The American Journal of Clinical Nutrition
|July 1, 1989
PubMed
Summary
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Multiple sclerosis (MS) patients show altered copper and zinc levels, particularly lower red blood cell copper, influenced by corticosteroid therapy. These trace element changes may serve as potential biomarkers for MS.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Clinical Medicine

Background:

  • Trace elements play crucial roles in biological processes.
  • Alterations in trace element homeostasis have been implicated in various neurological disorders.
  • Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system with complex etiologies.

Purpose of the Study:

  • To investigate trace element status in multiple sclerosis (MS) patients compared to healthy controls.
  • To assess the influence of corticosteroid treatment on trace element levels in MS patients.
  • To explore potential correlations between trace element status and disease characteristics in MS.

Main Methods:

  • Compared plasma and erythrocyte (RBC) trace element concentrations (ceruloplasmin, selenium, zinc, copper, glutathione peroxidase) in MS patients (n=27) and healthy controls.

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  • Stratified MS patients based on corticosteroid treatment.
  • Analyzed correlations between RBC copper and zinc, and disease acuity/disability.

    • Main Results:

    • Plasma ceruloplasmin, selenium, and zinc, and RBC glutathione peroxidase, selenium, and zinc were similar across all groups.
    • RBC copper concentrations were significantly lower in MS patients compared to controls.
    • Corticosteroid therapy was associated with decreased RBC copper levels in MS patients.
    • RBC zinc-to-copper ratios were significantly higher in MS patients.
    • RBC copper levels correlated significantly with RBC zinc in both MS patients and controls.
    • Disease acuity and disability did not affect trace-mineral status.

    Conclusions:

    • MS patients exhibit altered copper and zinc homeostasis, characterized by reduced RBC copper and elevated RBC Zn-Cu ratios.
    • Corticosteroid therapy influences copper metabolism in MS patients.
    • These systemic trace element alterations may be indicative of MS pathogenesis or a consequence of the disease.
    • Trace element status could potentially serve as clinically useful biomarkers for MS.