Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-world management of oral mucositis/stomatitis among patients with advanced non-small cell lung cancer (NSCLC) or breast cancer (BC).

Future oncology (London, England)·2026

Same author

Review of shortwave infrared imaging and spectroscopy in tissue [Invited].

Biomedical optics express·2025

Same author

Shortwave infrared spatial frequency domain imaging for detection of changes in tissue hydration.

Frontiers in photonics·2025

Same author

Does the relationship between stress and quality of life differ among informal caregivers of older adults with Alzheimer's disease and children with autism spectrum disorder? Results from a cross-sectional survey.

Journal of patient-reported outcomes·2025

Same author

Prenatal air pollution exposure and placental vasculature development among participants of the UPSIDE cohort study.

Environmental research·2025

Same author

Changes in Corneal Keratocytes and Collagen Fibrils as an Indicator of Keratoconus Onset: A Preliminary Study Based on OCT Subchannel Images.

Frontiers in bioscience (Landmark edition)·2025

Search research articles

Related Experiment Video

Updated: Mar 16, 2026

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Published on: December 13, 2016

A method for nondestructive mechanical testing of tissues and implants.

Ruchit Shah¹, Mark C Pierce¹, Frederick H Silver²

¹Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey.

Journal of Biomedical Materials Research. Part A

|August 11, 2016

Summary

This study introduces a new nondestructive vibrational testing method to determine the mechanical modulus of tissues and implant materials. This technique offers a simpler alternative to traditional stress-strain measurements for complex materials.

Keywords:

biomaterials collagen dermis extracellular matrix mechanical properties modulus optical coherence tomography silicone skin vibration viscoelasticity

More Related Videos

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

Related Experiment Videos

Last Updated: Mar 16, 2026

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Published on: December 13, 2016

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

Area of Science:

Biomaterials Science
Tissue Engineering
Mechanical Engineering

Background:

Traditional mechanical testing of tissues and implants is often destructive and limited in application.
Developing nondestructive methods is crucial for in vivo analysis and improved implant design.

Purpose of the Study:

To demonstrate a novel nondestructive in vitro testing approach.
To evaluate the efficacy of combining optical coherence tomography (OCT) and vibrational analysis.
To assess the mechanical properties of a tissue model (decellularized human dermis) and a model implant (silicone rubber).

Main Methods:

Utilized a combination of optical coherence tomography (OCT) and vibrational analysis.
Applied these methods to decellularized human dermis and silicone rubber samples.
Compared results with traditional tensile stress-strain measurements.

Main Results:

Nondestructive vibrational testing successfully determined the modulus of polymeric materials.
Results obtained were comparable to those from conventional tensile stress-strain measurements.
This method bypasses the need to approximate the tangent to the stress-strain curve, simplifying analysis for nonlinear materials.

Conclusions:

Nondestructive vibrational testing is a viable method for assessing the mechanical modulus of biomaterials and tissue models.
This technique offers advantages over traditional methods, particularly for nonlinear materials.
Further development could enable in vivo applications for tissue pathology analysis and implant material design.